| Title |
RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans
|
|---|---|
| Published in |
PLOS ONE, December 2009
|
| DOI | 10.1371/journal.pone.0008210 |
| Pubmed ID | |
| Authors |
Paola Sebastiani, Monty Montano, Annibale Puca, Nadia Solovieff, Toshio Kojima, Meng C. Wang, Efthymia Melista, Micah Meltzer, Sylvia E. J. Fischer, Stacy Andersen, Stephen H. Hartley, Amanda Sedgewick, Yasumichi Arai, Aviv Bergman, Nir Barzilai, Dellara F. Terry, Alberto Riva, Chiara Viviani Anselmi, Alberto Malovini, Aya Kitamoto, Motoji Sawabe, Tomio Arai, Yasuyuki Gondo, Martin H. Steinberg, Nobuyoshi Hirose, Gil Atzmon, Gary Ruvkun, Clinton T. Baldwin, Thomas T. Perls |
| Abstract |
The strong familiality of living to extreme ages suggests that human longevity is genetically regulated. The majority of genes found thus far to be associated with longevity primarily function in lipoprotein metabolism and insulin/IGF-1 signaling. There are likely many more genetic modifiers of human longevity that remain to be discovered. |
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Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 6% |
| Germany | 3 | 2% |
| United Kingdom | 2 | 1% |
| Israel | 1 | <1% |
| Switzerland | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 149 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 25% |
| Researcher | 30 | 18% |
| Student > Master | 13 | 8% |
| Professor > Associate Professor | 13 | 8% |
| Student > Bachelor | 12 | 7% |
| Other | 33 | 20% |
| Unknown | 25 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 75 | 45% |
| Biochemistry, Genetics and Molecular Biology | 29 | 17% |
| Medicine and Dentistry | 16 | 10% |
| Psychology | 4 | 2% |
| Neuroscience | 4 | 2% |
| Other | 11 | 7% |
| Unknown | 28 | 17% |