The Serotonergic 5-HT2C Agonist m-Chlorophenylpiperazine Increases Weight-Supported Locomotion without Development of Tolerance in Rats with Spinal Transections
The direct serotonergic agonist, m-chlorophenylpiperazine (m-CPP), displays high efficacy at 5-HT(2C) receptors. Systemic administration of m-CPP increased dramatically the percentage of weight-supported steps made on a treadmill by rats with complete midthoracic spinal transections. The improvement in motor function occurred in rats with grafts of fetal spinal cord into the site of transection (transplant rats) and in spinal rats without grafts (spinal rats). m-CPP produced a therapeutic action with its first administration and after 14 single daily injections. In contrast, the serotonin and norepinephrine reuptake inhibitor, chlorimipramine (CMI), failed to enhance weight support during 21 days of treatment. The results imply that stimulating directly 5-HT(2C) receptors restores postural support after spinal injury. Thus, 5-HT(2C) agonists are candidates for treating spinal patients chronically without the development of tolerance.
Pharmacology, Toxicology and Pharmaceutical Science
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Other
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Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2006.
All research outputs
#10,715,099
of 30,878,141 outputs
Outputs from Experimental Neurology
#1,654
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Outputs of similar age
#20,245
of 52,377 outputs
Outputs of similar age from Experimental Neurology
#8
of 19 outputs
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