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Dystrophin gene abnormalities in two patients with idiopathic dilated cardiomyopathy

Overview of attention for article published in Heart, December 1997
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1 patent

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35 Mendeley
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Title
Dystrophin gene abnormalities in two patients with idiopathic dilated cardiomyopathy
Published in
Heart, December 1997
DOI 10.1136/hrt.78.6.608
Pubmed ID
Authors

F Muntoni, A Di Lenarda, M Porcu, G Sinagra, A Mateddu, G Marrosu, A Ferlini, M Cau, J Milasin, M A Melis, M G Marrosu, C Cianchetti, A Sanna, A Falaschi, F Camerini, M Giacca, L Mestroni

Abstract

Two new cases of dilated cardiomyopathy (DC) caused by dystrophinopathy are reported. One patient, a 24 year old man, had a family history of X linked DC, while the other, a 52 year old man, had sporadic disease. Each had abnormal dystrophin immunostaining in muscle or cardiac biopsy specimens, but neither had muscle weakness. Serum creatine kinase activity was raised only in the patient with familial disease. Analysis of dystrophin gene mutations showed a deletion of exons 48-49 in the patient with familial DC and of exons 49-51 in the other. Dystrophin transcription in cardiac tissue from the patient with sporadic disease showed abundant expression, predominantly of the muscle isoform. This study, together with previous reports, suggests that some patients with DC have a dystrophinopathy that can be diagnosed using a combination of biochemical and genetic analyses.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 34 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 20%
Student > Ph. D. Student 4 11%
Professor > Associate Professor 4 11%
Professor 3 9%
Student > Doctoral Student 2 6%
Other 8 23%
Unknown 7 20%
Readers by discipline Count As %
Medicine and Dentistry 10 29%
Agricultural and Biological Sciences 9 26%
Biochemistry, Genetics and Molecular Biology 3 9%
Neuroscience 3 9%
Computer Science 1 3%
Other 1 3%
Unknown 8 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2008.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Heart
#3,257
of 6,709 outputs
Outputs of similar age
#19,621
of 94,540 outputs
Outputs of similar age from Heart
#5
of 17 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,709 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.3. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,540 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.