The synthesis and structure-activity relationships of novel dipeptidyl peptidase IV inhibitors replacing the classical cyanopyrrolidine P1 group with other small nitrogen heterocycles are described. A unique potency enhancement was achieved with beta-branched natural and unnatural amino acids, particularly adamantylglycines, linked to a (2S,3R)-2,3-methanopyrrolidine based scaffold.
Pharmacology, Toxicology and Pharmaceutical Science
5
15%
Biochemistry, Genetics and Molecular Biology
4
12%
Medicine and Dentistry
3
9%
Agricultural and Biological Sciences
2
6%
Other
0
0%
Unknown
6
18%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2018.
All research outputs
#7,432,872
of 34,089,221 outputs
Outputs from Bioorganic & Medicinal Chemistry Letters
#5,534
of 17,533 outputs
Outputs of similar age
#26,462
of 118,417 outputs
Outputs of similar age from Bioorganic & Medicinal Chemistry Letters
#86
of 233 outputs
Altmetric has tracked 34,089,221 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 17,533 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 118,417 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 233 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
