| Title |
Auxiliary subunits: essential components of the voltage-gated calcium channel complex
|
|---|---|
| Published in |
Current Opinion in Neurobiology, June 2003
|
| DOI | 10.1016/s0959-4388(03)00066-7 |
| Pubmed ID | |
| Authors | |
| Abstract |
Voltage-gated calcium channels are important mediators of several physiological processes, including neuronal excitability and muscle contraction. At the molecular level, the channels are composed of four subunits--the pore forming alpha(1) subunit and the auxiliary alpha(2)delta, beta and gamma subunits. The auxiliary subunits modulate the trafficking and the biophysical properties of the alpha(1) subunit. In the past several years there has been an acceleration of our understanding of the auxiliary subunits, primarily because of their molecular characterization and the availability of spontaneous and targeted mouse mutants. These studies have revealed the crucial role of the subunits in the functional effects that are mediated by voltage-gated calcium channels. |
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Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 2% |
| Korea, Republic of | 1 | <1% |
| India | 1 | <1% |
| Spain | 1 | <1% |
| Germany | 1 | <1% |
| Austria | 1 | <1% |
| Unknown | 303 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 77 | 25% |
| Researcher | 59 | 19% |
| Student > Bachelor | 36 | 12% |
| Student > Master | 27 | 9% |
| Professor > Associate Professor | 18 | 6% |
| Other | 51 | 16% |
| Unknown | 45 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 118 | 38% |
| Neuroscience | 44 | 14% |
| Biochemistry, Genetics and Molecular Biology | 39 | 12% |
| Medicine and Dentistry | 23 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 4% |
| Other | 25 | 8% |
| Unknown | 52 | 17% |