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FGF8 coordinates tissue elongation and cell epithelialization during early kidney tubulogenesis

Overview of attention for article published in Development (09501991), June 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

Mentioned by

blogs
1 blog
twitter
5 X users
facebook
2 Facebook pages

Citations

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46 Dimensions

Readers on

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68 Mendeley
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Title
FGF8 coordinates tissue elongation and cell epithelialization during early kidney tubulogenesis
Published in
Development (09501991), June 2015
DOI 10.1242/dev.122408
Pubmed ID
Authors

Yuji Atsuta, Yoshiko Takahashi

Abstract

When a tubular structure forms during early embryogenesis, tubular elongation and lumen formation (epithelialization) proceed simultaneously in a spatiotemporally coordinated manner. We here demonstrate, using the Wolffian duct (WD) of early chicken embryos, that this coordination is regulated by the expression of FGF8, which shifts posteriorly during body axis elongation. FGF8 acts as a chemoattractant on the leader cells of the elongating WD and prevents them from epithelialization, whereas static ('rear') cells that receive progressively less FGF8 undergo epithelialization to form a lumen. Thus, FGF8 acts as a binary switch that distinguishes tubular elongation from lumen formation. The posteriorly shifting FGF8 is also known to regulate somite segmentation, suggesting that multiple types of tissue morphogenesis are coordinately regulated by macroscopic changes in body growth.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Canada 1 1%
Brazil 1 1%
Unknown 65 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 31%
Student > Ph. D. Student 16 24%
Professor > Associate Professor 5 7%
Student > Bachelor 3 4%
Professor 3 4%
Other 9 13%
Unknown 11 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 32%
Biochemistry, Genetics and Molecular Biology 15 22%
Engineering 7 10%
Medicine and Dentistry 3 4%
Psychology 1 1%
Other 2 3%
Unknown 18 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2015.
All research outputs
#3,312,789
of 25,371,288 outputs
Outputs from Development (09501991)
#1,973
of 9,469 outputs
Outputs of similar age
#40,525
of 277,309 outputs
Outputs of similar age from Development (09501991)
#39
of 92 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,469 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,309 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.