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Affinity Purification of a Human RNA Polymerase II Complex Using Monoclonal Antibodies against Transcription Factor IIF*

Overview of attention for article published in Journal of Biological Chemistry, April 1997
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Article details
Title
Affinity Purification of a Human RNA Polymerase II Complex Using Monoclonal Antibodies against Transcription Factor IIF*
Published in
Journal of Biological Chemistry, April 1997
DOI 10.1074/jbc.272.17.11495
Pubmed ID
Authors
Abstract

Five different monoclonal antibodies that immunoreact with RAP74, the large subunit of general transcription factor (TF) IIF, were produced and characterized. Using one of these antibodies, an affinity purification procedure was devised to isolate a human RNA polymerase II complex. This procedure is fast, simple, and reproducible and does not require extensive purification. The RNA polymerase II complex isolated using this procedure contains SRB (suppressor of RNA polymerase B) polypeptides, transcription factors IIE and IIF, limiting amounts of TFIIH, and the TATA-binding protein, but was devoid of TFIIB.

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Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Geographical breakdown
Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status
Readers by professional status Count As %
Researcher 5 38%
Student > Ph. D. Student 2 15%
Professor > Associate Professor 2 15%
Other 1 8%
Student > Bachelor 1 8%
Other 1 8%
Unknown 1 8%
Readers by discipline
Readers by discipline Count As %
Agricultural and Biological Sciences 8 62%
Biochemistry, Genetics and Molecular Biology 3 23%
Computer Science 1 8%
Unknown 1 8%