Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice

Overview of attention for article published in Immunity, July 2015

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What about passenger mutations? KO mice generated with 129-derived ES cells and backcrossed onto a C57BL/6 mouse background will retain a segment of 129 DNA around the targeted locus. Even after 10 or more backcrosses. This issue is largely ignore…

Only 8K? possible to screen all of these quickly, in ....decades. Would there be grant money to finance such massive katharsis? https://t.co/9P7gdKFIhU

RT @DucheneJohan: @RotAntal Well apparently 8000 genetically modified mice are derived from 129 ESCs... https://t.co/OEkAUeOmVi

@RotAntal Well apparently 8000 genetically modified mice are derived from 129 ESCs... https://t.co/OEkAUeOmVi

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