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Activity-Dependent Changes in the Intrinsic Properties of Cultured Neurons

Overview of attention for article published in Science, May 1994
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

Mentioned by

patent
2 patents
wikipedia
1 Wikipedia page

Readers on

mendeley
333 Mendeley
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Article details
Title
Activity-Dependent Changes in the Intrinsic Properties of Cultured Neurons
Published in
Science, May 1994
DOI 10.1126/science.8178157
Pubmed ID
Authors
Abstract

Learning and memory arise through activity-dependent modifications of neural circuits. Although the activity dependence of synaptic efficacy has been studied extensively, less is known about how activity shapes the intrinsic electrical properties of neurons. Lobster stomatogastric ganglion neurons fire in bursts when receiving synaptic and modulatory input but fire tonically when pharmacologically isolated. Long-term isolation in culture changed their intrinsic activity from tonic firing to burst firing. Rhythmic stimulation reversed this transition through a mechanism that was mediated by a rise in intracellular calcium concentration. These data suggest that neurons regulate their conductances to maintain stable activity patterns and that the intrinsic properties of a neuron depend on its recent history of activation.

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Mendeley demographics

Mendeley demographics

The data shown below were compiled from readership statistics for 333 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Geographical breakdown
Country Count As %
United States 13 4%
Israel 3 <1%
United Kingdom 3 <1%
France 3 <1%
Germany 3 <1%
Greece 2 <1%
Belgium 2 <1%
Sweden 1 <1%
Netherlands 1 <1%
Other 3 <1%
Unknown 299 90%

Demographic breakdown

Readers by professional status
Readers by professional status Count As %
Student > Ph. D. Student 104 31%
Researcher 66 20%
Student > Bachelor 24 7%
Student > Master 24 7%
Professor 20 6%
Other 49 15%
Unknown 46 14%
Readers by discipline
Readers by discipline Count As %
Agricultural and Biological Sciences 123 37%
Neuroscience 88 26%
Physics and Astronomy 13 4%
Medicine and Dentistry 13 4%
Engineering 11 3%
Other 30 9%
Unknown 55 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2023.
All research outputs
#4,077,620
of 26,871,714 outputs
Outputs from Science
#38,625
of 84,681 outputs
Outputs of similar age
#1,536
of 22,248 outputs
Outputs of similar age from Science
#52
of 211 outputs
Altmetric has tracked 26,871,714 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 84,681 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 66.3. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 22,248 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 211 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.