In prior studies from multiple groups, outcomes following experimental peripheral arterial disease (PAD) differed considerably across inbred mouse strains. Similarly in humans with PAD, disease outcomes differ even when there are similarities in risk factors, disease anatomy, arteriosclerotic burden and hemodynamic measures. We previously identified a locus on mouse chromosome 7 (LSq-1) that was sufficient to modify outcomes following experimental PAD.
We compared expression of genes within LSq-1 in Balb/c that normally show poor outcomes following experimental PAD to that in C57Bl/6 that normally show favorable outcomes, and found ADAM12, a disintegrin and metalloproteinase gene had the most differential expression. Augmentation of ADAM12 expression in vivo improved outcomes following experimental PAD in Balb/c mice while knock down of ADAM12 made outcomes worse in C56Bl/6 mice. In vitro, ADAM12 expression modulates endothelial cell proliferation, survival, and angiogenesis in ischemia and this appeared to be dependent on Tie2 activation.
ADAM12 is sufficient to modify PAD severity in mice and this likely occurs through regulation of Tie2.
Pharmacology, Toxicology and Pharmaceutical Science
1
3%
Other
4
11%
Unknown
13
36%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2015.
All research outputs
#23,297,651
of 34,360,889 outputs
Outputs from American Journal of Physiology: Heart & Circulatory Physiology
#5,906
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Outputs of similar age
#184,276
of 301,875 outputs
Outputs of similar age from American Journal of Physiology: Heart & Circulatory Physiology
#33
of 72 outputs
Altmetric has tracked 34,360,889 research outputs across all sources so far. This one is in the 30th percentile – i.e., 30% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,398 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
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We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
