Title |
The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis
|
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Published in |
Journal of Rheumatology, December 2008
|
DOI | 10.3899/jrheum.080346 |
Pubmed ID | |
Authors |
Massoud Daheshia, Jian Q Yao |
Abstract |
Osteoarthritis (OA) is a major disabling disease and is ranked as a major cause of chronic pain in adults. The pathology of the illness is characterized by a loss of articular cartilage leading to narrowing of joint space, increased joint friction, potential structural remodeling, persistent pain, and functional impairment. The proinflammatory cytokine interleukin 1beta (IL-1beta) has several chemical and bioactive characteristics allowing this catabolic protein to be involved in initiation and progression of OA. We review the current understanding of the pathogenesis of OA, and how upregulation of IL-1beta initiates a cascade of intracellular events that can culminate in activation of proteinases, creation of a pro-destructive articular milieu, suppression of anabolic pathways, and a decrease in the synthesis of cartilage extracellular matrix. Therapeutic approaches to block the action of IL-1beta and overcome its signal transduction to curtail disease progression are discussed. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Mexico | 1 | <1% |
United States | 1 | <1% |
Unknown | 161 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 33 | 20% |
Researcher | 19 | 12% |
Student > Bachelor | 19 | 12% |
Student > Master | 13 | 8% |
Student > Doctoral Student | 8 | 5% |
Other | 33 | 20% |
Unknown | 39 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 28 | 17% |
Agricultural and Biological Sciences | 27 | 16% |
Medicine and Dentistry | 25 | 15% |
Engineering | 12 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
Other | 21 | 13% |
Unknown | 45 | 27% |