Several factors contribute to nuclear mRNA export in Saccharomyces cerevisiae, including Mex67p, Mtr2p, Gle1p, Nup159p, Dbp5p, and Rip1p. Strains carrying mutations in these factors show rapid and dramatic nuclear accumulation of poly(A)(+) RNA. We have characterized two heat shock mRNAs, SSA4 and HSP104, in these mutant backgrounds; each transcript concentrates in a single intranuclear focus. Evidence suggests that it coincides with the site of transcription. Interestingly, all detectable SSA4 transcripts have undergone 3'-end formation, indicating that RNAs in the foci are no longer nascent. Poly(A) tails of the transcripts are also dramatically longer in all of these export mutants. Based on all of the data, we suggest that very early mRNA maturation events determine transcript export competence.
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2021.
All research outputs
#6,087,116
of 27,781,301 outputs
Outputs from Molecular Cell
#4,421
of 8,028 outputs
Outputs of similar age
#8,969
of 48,733 outputs
Outputs of similar age from Molecular Cell
#14
of 41 outputs
Altmetric has tracked 27,781,301 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 8,028 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.7. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
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We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
