To determine predictors of parenteral antibiotic duration and the association between parenteral treatment duration and relapses in infants <3 months with bacteraemic urinary tract infection (UTI).
Multicentre retrospective cohort study.
Eleven healthcare institutions across the USA.
Infants <3 months of age with bacteraemic UTI, defined as the same pathogenic organism isolated from blood and urine.
Duration of parenteral antibiotic therapy, relapsed UTI within 30 days.
The mean (±SD) duration of parenteral antibiotics for the 251 included infants was 7.8 days (±4 days), with considerable variability between institutions (mean range 5.5-12 days). Independent predictors of the duration of parenteral antibiotic therapy included (coefficient, 95% CI): age (-0.2 days, -0.3 days to -0.08 days, for each week older), year treated (-0.2 days, -0.4 to -0.03 days for each subsequent calendar year), male gender (0.9 days, 0.01 to 1.8 days), a positive repeat blood culture during acute treatment (3.5 days, 1.2-5.9 days) and a non-Escherichia coli organism (2.2 days, 0.8-3.6 days). No infants had a relapsed bacteraemic UTI. Six infants (2.4%) had a relapsed UTI (without bacteraemia). The duration of parenteral antibiotics did not differ between infants with and without a relapse (8.2 vs 7.8 days, p=0.81).
Parenteral antibiotic treatment duration in young infants with bacteraemic UTI was variable and only minimally explained by measurable patient factors. Relapses were rare and were not associated with treatment duration. Shorter parenteral courses may be appropriate in some infants.
Pharmacology, Toxicology and Pharmaceutical Science
2
3%
Immunology and Microbiology
2
3%
Social Sciences
2
3%
Veterinary Science and Veterinary Medicine
1
2%
Other
2
3%
Unknown
19
31%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2021.
All research outputs
#2,060,892
of 28,027,355 outputs
Outputs from Archives of Disease in Childhood
#822
of 8,693 outputs
Outputs of similar age
#23,452
of 279,199 outputs
Outputs of similar age from Archives of Disease in Childhood
#12
of 79 outputs
Altmetric has tracked 28,027,355 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,693 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.1. This one has done particularly well, scoring higher than 90% of its peers.
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We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.
