Heteromerization of G protein-coupled receptors (GPCR) can significantly change the functional properties of involved receptors. Various biochemical and biophysical methodologies have been developed the last two decades to identify and functionally evaluate GPCR heteromers in heterologous cells, with recent approaches focusing on GPCR complex stoichiometry and stability. Yet, validation of these observations in native tissues is still lacking behind for the majority of GPCR heteromers. Remarkably, recent studies, particularly some involving advanced fluorescence microscopy techniques, are contributing to our current knowledge on aspects that were not well known till now such as GPCR complex stoichiometry and stability. In parallel, a growing effort is being applied to move the field forward into native systems. This short review will highlight recent developments to study stoichiometry and stability of GPCR complexes and methodologies to detect native GPCR dimers.
Pharmacology, Toxicology and Pharmaceutical Science
6
10%
Medicine and Dentistry
4
6%
Other
10
16%
Unknown
10
16%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2015.
All research outputs
#21,378,026
of 31,802,852 outputs
Outputs from Molecular Pharmacology
#4,543
of 5,261 outputs
Outputs of similar age
#171,420
of 292,300 outputs
Outputs of similar age from Molecular Pharmacology
#25
of 38 outputs
Altmetric has tracked 31,802,852 research outputs across all sources so far. This one is in the 30th percentile – i.e., 30% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,261 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
