To compare pathologic characteristics, treatment patterns and survival in patients with ductal adenocarcinoma (DC) compared to those with acinar adenocarcinoma (AC).
Using the National Cancer Database (NCDB), we identified patients diagnosed with clinically localized (cN0, cM0) pure DC (n=1,328) and AC (n=751,635) between 1998 and 2011. High-risk AC was defined as Gleason 8-10. Demographic, treatment, pathological and survival characteristics of patients were compared.
Compared to patients with Gleason 8-10 AC, those with DC presented with lower mean PSA (10.3 vs 16.2 ng/mL, p<0.001), had similar rates (11.7% vs 11.5%, p=0.8) of clinical extra-capsular extension (stage ≥ cT3), and were more likely to undergo prostatectomy (54% vs 36%, p<0.001). Compared to patients with Gleason 8-10 AC undergoing prostatectomy, those with DC had more favorable pathology: stage ≥ T3 (39% vs 52%, p<0.001), fewer positive lymph nodes (4% vs 11%, p<0.001) and fewer positive margins (25% vs 33%, p<0.001). On Kaplan-Meier analysis, patients with DC had similar 5 year survival (75.0%, 95% CI: [71.7-78.9]) compared to those with Gleason 8-10 AC (77.1%, 95% CI: [76.6%-77.6%], p=0.2). On Cox multivariable analysis, patients with Gleason 8-10 AC had a similar risk of death compared to those with DC (HR=0.92, 95% CI [0.69-1.23], p=0.6).
In this large contemporary population-based series, patients with ductal adenocarcinoma of the prostate presented with lower PSA, had more favorable pathologic features, and similar overall survival compared to men with Gleason 8-10 AC.
Pharmacology, Toxicology and Pharmaceutical Science
2
5%
Computer Science
2
5%
Biochemistry, Genetics and Molecular Biology
1
3%
Mathematics
1
3%
Other
2
5%
Unknown
12
31%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2015.
All research outputs
#7,198,593
of 25,373,627 outputs
Outputs from Urology
#2,457
of 7,811 outputs
Outputs of similar age
#77,442
of 275,396 outputs
Outputs of similar age from Urology
#38
of 182 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 7,811 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,396 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 182 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.
