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Mendeley readers
Attention Score in Context
| Title |
Neonatal androgenization affects the efficiency of β-adrenoceptor-mediated modulation of thymopoiesis
|
|---|---|
| Published in |
Journal of Neuroimmunology, September 2011
|
| DOI | 10.1016/j.jneuroim.2011.08.020 |
| Pubmed ID | |
| Authors |
Katarina Radojević, Duško Kosec, Milica Perišić, Ivan Pilipović, Biljana Vidić-Danković, Gordana Leposavić |
| Abstract |
We tested the hypothesis that neonatal androgenization affects the efficacy of β-adrenoceptor (β-AR)-mediated fine tuning of thymopoiesis in adult female rats by modulating the thymic noradrenaline (NA) level and/or β-AR expression. In adult rats administered with 1000 μg testosterone enanthate at postnatal day 2 a higher density of catecholamine (CA)-synthesizing thymic cells, including thymocytes, and a rise in their CA content was found. In addition, in these animals increased thymic noradrenergic nerve fiber fluorescence intensity, reflecting their increased CA content, was detected. These changes were followed by an increase in thymic NA concentration. The rise in thymic NA content in thymic nerve fibers and cells was associated with changes in the expression of mRNA for enzymes controlling pivotal steps in NA biosynthesis (tyrosine hydroxylase, dopamine-β-hydroxylase) and inactivation (monoamine oxidase). In contrast, the thymic level of β(2)-AR mRNA on a per cell basis and the receptor surface density on thymocytes was reduced in testosterone-treated (TT) rats. As a consequence, 14-day-long treatment with propranolol, a β-AR blocker, was ineffective in modulating T-cell differentiation/maturation in TT rats. In conclusion, the study indicates the importance of the neonatal sex steroid milieu for shaping the immunomodulatory capacity of the thymic NA/β-AR signaling system in adult rats. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 4% |
| Portugal | 1 | 4% |
| France | 1 | 4% |
| Unknown | 20 | 87% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 26% |
| Student > Ph. D. Student | 4 | 17% |
| Student > Master | 4 | 17% |
| Student > Bachelor | 3 | 13% |
| Student > Postgraduate | 2 | 9% |
| Other | 4 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 4 | 17% |
| Psychology | 3 | 13% |
| Agricultural and Biological Sciences | 3 | 13% |
| Medicine and Dentistry | 3 | 13% |
| Neuroscience | 3 | 13% |
| Other | 6 | 26% |
| Unknown | 1 | 4% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2011.
All research outputs
#16,721,717
of 25,374,647 outputs
Outputs from Journal of Neuroimmunology
#2,109
of 3,012 outputs
Outputs of similar age
#97,477
of 141,276 outputs
Outputs of similar age from Journal of Neuroimmunology
#10
of 16 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,012 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 141,276 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.