Vesical pleomorphic giant cell carcinoma (PGCC) is a variant of urothelial carcinoma (UC) characterized by highly pleomorphic tumour with giant cells. Less than 10 cases have been reported and our aim was to determine the clinical and pathological features of a series of tumours from a specialized uropathology laboratory.
Thirteen cases of PGCC of the bladder were identified. There were 9 males and 4 females ranging in age from 53-92 years (mean 72 years). Associated conventional high grade UC was seen in 8 cases, while 3 cases also had micropapillary UC and 1 plasmacytoid UC. UC in situ (CIS) was present in 5 cases and occasional bizarre cells were seen in both UC and CIS. The proportion of PGCC present varied from 40% to 100% of tumour. Immunostaining performed on 10 cases showed uniform positivity for CK 8/18 and AE1/AE3, while most tumours were positive for CK7, CK20, Uroplakin III, and GATA-3. β hCG was negative. Of 10 patients with follow-up, 5 died within 1 year and 4 are alive with tumour.
The association of PGCC with UC and an overlap in immunoexpression suggests that PGCC represents an extreme form of UC de-differentiation. This article is protected by copyright. All rights reserved.
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2015.
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