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Cholesterol bound to hemoglobin in normal human erythrocytes: a new form of cholesterol in circulation?

Overview of attention for article published in Clinical Biochemistry, January 2004
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1 patent

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Title
Cholesterol bound to hemoglobin in normal human erythrocytes: a new form of cholesterol in circulation?
Published in
Clinical Biochemistry, January 2004
DOI 10.1016/j.clinbiochem.2003.10.002
Pubmed ID
Authors

Milan Nikolić, Dragana Stanić, Nadežda Antonijević, Vesna Niketić

Abstract

To study lipid fraction that is occasionally observed in red blood cell (RBC) hemolysate (supernatants from which membranes were separated). Plasma lipid profiles, cholesterol (Ch) and phospholipids (PL) in intact RBCs, RBC membranes and hemolysates were examined in young healthy male population in winter and summer. The RBC Ch and PL content was significantly higher than in membranes, both in winter and summer. The "excess" of cholesterol (associated with phospholipid) was bound to hemoglobin yielding Hb-lipid adduct (Hb-Ch), the pools in the RBC membrane remaining virtually unaltered. Levels of hemoglobin-lipid complex (Hb-Ch), which were significantly higher in winter than in summer (30% and 19% of the total Hb, respectively), positively correlated with plasma HDL cholesterol levels. To our knowledge, this is the first demonstration of cholesterol binding to Hb. The results suggest influence of plasma lipoprotein metabolism on the formation of Hb-Ch.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 33%
Researcher 2 17%
Student > Master 2 17%
Student > Bachelor 1 8%
Student > Doctoral Student 1 8%
Other 0 0%
Unknown 2 17%
Readers by discipline Count As %
Medicine and Dentistry 5 42%
Biochemistry, Genetics and Molecular Biology 3 25%
Immunology and Microbiology 1 8%
Unknown 3 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2017.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Clinical Biochemistry
#578
of 2,317 outputs
Outputs of similar age
#36,568
of 143,821 outputs
Outputs of similar age from Clinical Biochemistry
#3
of 6 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,317 research outputs from this source. They receive a mean Attention Score of 3.9. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 143,821 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.