An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

@Sci_Hans Certainly a cool idea -- both open/closed can be resolved in P 31 2 1. @DanielKeedy has a paper where they use temperature to bias the equilibrium (https://t.co/tFzTJn5sWz)

@AlexisRohou I'm thinking of stuff such as this, which is a very different collection of structures than e.g. a 20mer NMR ensemble, a "minor population" label, or a "proper" dynamic ensemble. Labelling and understanding the differences is key https://t.…

New routes for PTP1B allosteric inhibition by multitemperature crystallography, fragment screening and covalent tethering published as: https://t.co/PCeUTb7txL @eLife #biorxiv

RT @fraser_lab: using multitemperature crystallography to discovery new ways to allosterically inhibit enzymes by (former) postdoc @DanielK…