Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer with PTV<100cc using a continual reassessment method (JCOG0702)
To estimate the maximum tolerated dose (MTD) and to determine the recommended dose (RD) of stereotactic body radiation therapy (SBRT) for peripheral T2N0M0 non-small cell carcinoma (NSCLC) with target volume (PTV) < 100cc.
The continual reassessment method (CRM) was used to determine the dose level that patients should be assigned to and to estimate the MTD. Dose limiting toxicity (DLT) was grade 3 radiation pneumonitis (RP) within 180days after the start of SBRT, grade 2 RP was used as a surrogate DLT. The RD was equal to the MTD. The dose was prescribed at D95 of the PTV.
Fifteen patients were accrued. Only 1 experienced grade 2 RP at 60Gy in 4 fractions. It was difficult to fulfill the dose constraints at 60Gy in 4 fractions, and the maximum dose level assigned by CRM was changed to 55Gy in 4 fractions. The lower limit of 95% of the credible interval exceeded the adjacent level, and the RD was determined as 55Gy in 4 fractions.
The RD of SBRT for peripheral T2N0M0 NSCLC with PTV<100cc was determined to be 55Gy in 4 fractions.
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2016.
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