Grading is an important prognostic parameter for prostate adenocarcinoma and renal cell carcinoma (RCC); however, the most frequently used classifications fail to account for advances in our understanding of the diagnostic features, classification and/or behaviour of these tumors. In 2005 and 2014 the International Society of Urological Pathology (ISUP) formalised changes to Gleason scoring (GS) with the adoption of ISUP grading for prostate cancer in 2014. [Grade 1- GS 3+3, Grade 2-GS 3+4, Grade 3-GS 4+3, Grade 4-GS 8, Grade 5-GS 9-10]. Internationally the Fuhrman grading system is widely employed despite criticisms relating to its application, validity and reproducibility. In 2012 the ISUP established a grading system for RCC. [Grade 1, the nucleolus is not seen or is inconspicuous and basophilic at 400x magnification. Grade 2, nucleoli are eosinophilic and clearly visible at 400x magnification. Grade 3, nucleoli are clearly visible at 100x magnification. Grade 4, tumors show extreme pleomorphism or rhabdoid and/or sarcomatoid morphology]. This grading has been validated for clear cell RCC and papillary RCC. It was further recommended that chromophobe RCC not be graded. For other morphotypes of RCC ISUP grading has not been validated as a prognostic parameter, but can be used for descriptive purposes. This article is protected by copyright. All rights reserved.
Pharmacology, Toxicology and Pharmaceutical Science
1
1%
Biochemistry, Genetics and Molecular Biology
1
1%
Nursing and Health Professions
1
1%
Agricultural and Biological Sciences
1
1%
Other
2
3%
Unknown
16
24%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2016.
All research outputs
#2,680,617
of 31,266,886 outputs
Outputs from Histopathology
#208
of 4,060 outputs
Outputs of similar age
#28,141
of 284,446 outputs
Outputs of similar age from Histopathology
#6
of 50 outputs
Altmetric has tracked 31,266,886 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,060 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,446 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.
