Retrospective study of Nationwide Inpatient Sample (NIS)Objective. Objective of this study is to estimate the prevalence of complications in children who had insertion of recombinant human Bone Morphogenetic Protein (rhBMP) at the time of Spinal Fusion Procedures (SFP) and to examine if the use of rhBMP is associated with an increased risk of complications.
Use of rhBMP for SFP has been associated with conflicting safety profile reports in adults.
NIS (years 2004-2010) was used. All patients <18 years who had a SFP during hospitalization with or without insertion of rhBMP were selected. Complications were selected based on a literature review of studies examining outcomes of SFP. Association between insertion of rhBMP and occurrence of complications was examined by multivariable logistic regression models.
Of the 72,898 children who underwent SFP, 7.1% had insertion of rhBMP. Overall complication rate was 14.34% (15.2% in rhBMP group and 14.3% in no-rhBMP group). There was no statistically significant difference in the overall complication rate (OR = 1.08, 95% CI = 0.89-1.30) or among fourteen different complications between rhBMP and no-rhBMP groups. Children who had rhBMP were associated with higher odds for "other infections" (OR = 2.09, 95% CI = 1.26-3.48, p = 0.004) when compared to their counterparts.
Despite the lack of FDA approval, rhBMP was not infrequently used in pediatric SFP. In this large retrospective study using administrative data, the use of rhBMP in children during SFP was not associated with higher risks for majority of assessed complications with the exception of "other infections". Future studies must examine the long-term impact of use of rhBMP in children with SFP.
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2015.
All research outputs
#3,113,450
of 25,373,627 outputs
Outputs from Spine
#886
of 8,451 outputs
Outputs of similar age
#42,067
of 294,811 outputs
Outputs of similar age from Spine
#15
of 112 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,451 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,811 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 112 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.
