Title |
Molecular characterization and immune responsive expression of feline MDA5 gene
|
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Published in |
Journal of Veterinary Medical Science, July 2018
|
DOI | 10.1292/jvms.17-0278 |
Pubmed ID | |
Authors |
KOBA Ryota, Sakurako SHOJI, Sawami YOSHIMURA, Yukinobu TOHYA |
Abstract |
The retinoic acid-inducible gene-I-like receptor (RLR) family is a group of cytosolic RNA helicase proteins that play an important role in sensing viral RNAs. Melanoma differentiation-associated gene 5 (MDA5), an RLR protein, recognizes viral double-stranded RNA and 5'-triphosphate single-stranded RNA in the cytoplasm for the expression of type I interferon (IFN). The expression of MDA5 is also induced by type I IFN. In the present study, we determined the complete coding sequence of the feline MDA5 gene, and analyzed its structure. In addition, we examined tissue expression patterns, inducibilities of the feline MDA5 by polyinosinic-polycytidylic acid and type I IFN, and a functional role of feline MDA5 on type I IFN expression. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 2 | 29% |
Student > Master | 1 | 14% |
Student > Bachelor | 1 | 14% |
Professor > Associate Professor | 1 | 14% |
Student > Postgraduate | 1 | 14% |
Other | 0 | 0% |
Unknown | 1 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 2 | 29% |
Biochemistry, Genetics and Molecular Biology | 2 | 29% |
Immunology and Microbiology | 1 | 14% |
Medicine and Dentistry | 1 | 14% |
Unknown | 1 | 14% |