ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma

@notSoJunkDNA Neat paper showing how ETS binding rotates adjacent pyrimidines such that their C5-C6 bonds are closer to parallel, a more optimal conformation to form a cyclobutane dimer: https://t.co/TESAZu7M6C

ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma. https://t.co/bcd9KvlSII

UV-induced DNA damage is the major risk factor for melanoma. DNA damage links to onset of skin cancer, melanoma mapped. ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma. More info: https://t.co…

My recent publication shows DNA binding by ETS transcription factors is intrinsically mutagenic in UV-exposed human cells. New mechanism for mutation hotspots in gene promoters. https://t.co/rnkrbhOma4