Postmenopausal women experience undesired symptoms that adversely affect their quality of life. In the recent years, a specific 12 - week fractional CO2laser treatment has been introduced, with highly significant relief of symptoms.
The aim of this paper is the identification of the early modifications of structural components of atrophic vaginal mucosa induced by laser irradiation, which is responsible for the restorative processes.
We investigated by microscopical, ultrastructural and biochemical methods the modifications of the structural components of postmenopausal atrophic vaginal mucosa tissues after 1 hour following a single fractional laser CO2application.
In one hour, the mucosal epithelium thickens, with the maturation of epithelial cells and desquamation at the epithelial surface. In the connective tissue, new papillae indenting the epithelium with newly formed vessels penetrating them, new thin fibrils of collagen III are also formed in a renewed turnover of components due to the increase of metalloproteinase - 2. Specific features of fibroblasts support stimulation of their activity responsible of the renewal of the extracellular matrix, with an increase of mechanical support as connective tissue and stimulation of growth and maturation to epithelium thanks to new vessels and related factors delivered.
We found the activation of regenerative mechanisms expressed both in the connective tissue - with the formation of new vessels, new papillae, and new collagen - and in the epithelium with the associated thickening and desquamation of cells at the mucosal surface.
Pharmacology, Toxicology and Pharmaceutical Science
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3%
Business, Management and Accounting
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3%
Energy
2
3%
Biochemistry, Genetics and Molecular Biology
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Other
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6%
Unknown
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36%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2018.
All research outputs
#17,730,887
of 25,988,468 outputs
Outputs from Open Access Macedonian Journal of Medical Sciences
#44
of 90 outputs
Outputs of similar age
#289,642
of 455,091 outputs
Outputs of similar age from Open Access Macedonian Journal of Medical Sciences
#1
of 1 outputs
Altmetric has tracked 25,988,468 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 90 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.9. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
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