Induction of adaptive immunity leads to the establishment of immunological memory; however, how innate immunity regulates memory T cell function remains obscure. Here we show a previously undefined mechanism in which innate and adaptive immunity are linked by TRIF during establishment and re-activation of memory T cells against Gram-negative enteropathogens. Absence of TRIF in macrophages (Mφs) but not dendritic cells led to a predominant generation of CD4+ central memory T cells that express IL-17 during enteric bacterial infection in mice. TRIF-dependent type I IFN signaling in T cells was essential to Th1 lineage differentiation and re-activation of memory T cells. TRIF activated memory T cells to facilitate local neutrophil influx and enhance bacterial elimination. These results highlight the importance of TRIF as a mediator of the innate and adaptive immune interactions in achieving the protective properties of memory immunity against Gram-negative bacteria, and suggest TRIF as a potential therapeutic target.
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2022.
All research outputs
#6,646,467
of 34,089,221 outputs
Outputs from Infection and Immunity
#3,839
of 16,771 outputs
Outputs of similar age
#63,599
of 304,394 outputs
Outputs of similar age from Infection and Immunity
#15
of 76 outputs
Altmetric has tracked 34,089,221 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 16,771 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 304,394 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.
