Recipients of kidney transplantation have elevated risk of developing cancer. There are limited data on cancer risk in recipients of kidney retransplantation. We used data from the Transplant Cancer Match Study, which links the U.S. transplant registry with 15 cancer registries. Cancer incidence in recipients of kidney retransplantation and primary kidney transplants was compared utilizing Poisson regression, adjusting for demographic and medical characteristics. We assessed 109,224 primary recipients and 6,621 retransplants. Compared to primary recipients, retransplants were younger (median age 40 vs. 46 years), had higher PRA, and more often received induction with polyclonal antibodies (43% vs. 25%). A total of 5,757 cancers were observed in primary recipients and 245 in retransplants. Overall cancer risk was similar in retransplants compared with primary recipients (incidence rate ratio [IRR] 1.06, 95%CI 0.93-1.20, adjusted for age, gender, race/ethnicity, PRA, and use of polyclonal induction). However, renal cell carcinoma (RCC) occurred in excess among retransplants (adjusted IRR 2.03, 95%CI 1.45-2.77), based on 514 cases in primary recipients and 43 cases in retransplants. Overall cancer risk did not differ in retransplants compared to primary recipients. Increased risk of RCC may be explained by the presence of acquired cystic kidney disease, which is more likely to develop with additional time with kidney disease and time spent on dialysis waiting for retransplantation. This article is protected by copyright. All rights reserved.
Pharmacology, Toxicology and Pharmaceutical Science
1
6%
Nursing and Health Professions
1
6%
Psychology
1
6%
Other
0
0%
Unknown
6
38%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2015.
All research outputs
#19,985,639
of 24,558,777 outputs
Outputs from Clinical Transplantation
#1,145
of 1,541 outputs
Outputs of similar age
#198,942
of 272,541 outputs
Outputs of similar age from Clinical Transplantation
#7
of 17 outputs
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