Title |
The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms
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Published in |
Advances in skin & wound care (Print), August 2018
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DOI | 10.1097/01.asw.0000540070.07040.70 |
Pubmed ID | |
Authors |
Ivana irkovi, Dario Joci, Dragana D. Boi, Slobodanka Djuki, Neda Konstantinovi, Djordje Radak |
Abstract |
Biofilm-associated wound infections are a major global health issue, and methicillin-resistant Staphylococcus aureus (MRSA) is among the greatest therapeutic challenges. Vacuum-assisted closure (VAC) therapy is now being revisited as an alternative treatment for both acute and chronic wounds. However, data supporting the concept of its antibiofilm effect remain limited. Using quantitative biofilm-forming assay and a range of genotypic methods (spa, SCCmec, and agr typing), study authors showed that VAC therapy can significantly prevent biofilm formation (P < .01) of a range of MRSA wound isolates differing widely in their biofilm-forming abilities and genetic background. The best effect was presented on CC5-MRSA-SCCmecI-agrII, a dominant MRSA clone among wound isolates worldwide. An assessment of effects of different protocols on dressing changes (1 or 2 times per week) demonstrated significantly greater antibiofilm activity (P < .05) of 3-day dressing changes. These findings support the use of VAC therapy as a topical antibiofilm treatment for the effective management of wound healing. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 3 | 15% |
Student > Master | 3 | 15% |
Professor | 2 | 10% |
Other | 2 | 10% |
Student > Postgraduate | 2 | 10% |
Other | 1 | 5% |
Unknown | 7 | 35% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 35% |
Nursing and Health Professions | 3 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 10% |
Agricultural and Biological Sciences | 1 | 5% |
Materials Science | 1 | 5% |
Other | 0 | 0% |
Unknown | 6 | 30% |