Duchenne Muscular Dystrophy (DMD) has been well characterized as a disease that affects both skeletal muscle and bone. The pathophysiology responsible for the deficits in bone tissue is still unclear.
qRT-PCR and western blot analyses of known myokines from skeletal muscle were performed on dystrophic mouse models and WT controls to identify differentially expressed bone-regulating myokines.
24 out of 43 myokine genes demonstrated significantly different mRNA expression in the skeletal muscles of dystrophic mice when compared with muscles of WT mice. Several differently expressed bone-regulating myokine genes were identified, and their protein levels were also verified by western blot.
Dystrophic skeletal muscle demonstrated a significantly altered myokine gene expression profile. mRNA and protein levels of several bone-regulating myokines were significantly altered in dystrophic skeletal muscle, which suggests pathological role of bone-regulating myokines on bone homeostasis in DMD. This article is protected by copyright. All rights reserved.
Pharmacology, Toxicology and Pharmaceutical Science
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Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2018.
All research outputs
#21,879,071
of 24,411,829 outputs
Outputs from Muscle & Nerve
#2,655
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Outputs of similar age
#296,417
of 339,411 outputs
Outputs of similar age from Muscle & Nerve
#38
of 44 outputs
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