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Anticancer Activity of Organogallium(III) Complexes in Colon Cancer Cells.

Overview of attention for article published in Anti-Cancer Agents in Medicinal Chemistry, January 2016
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Title
Anticancer Activity of Organogallium(III) Complexes in Colon Cancer Cells.
Published in
Anti-Cancer Agents in Medicinal Chemistry, January 2016
DOI 10.2174/1871520615666151007160319
Pubmed ID
Authors

Milena R Kaluđerović, Marija Mojić, Santiago Gómez-Ruiz, Sanja Mijatović, Danijela Maksimović-Ivanić

Abstract

In vitro antitumor activity of various organogallium(III) complexes (1-8) have been tested against CT26CL25, HCT116, SW480 colon cancer cell lines. CV and MTT assays were used to asses on the antiproliferative effect of investigated organogallium(III) complexes. From the investigated complexes the most active was found to be tetranuclear compound 8 against CT26CL25 cells. Flow cytometric analysis of the CT26CL25 cells upon treatment with 8 was performed in order to determine the role of apoptosis, caspase activation, autophagy and proliferation rate on the cell death caused with this compound. Results indicate cytotoxic potential of the tetranuclear complex 8 by inducing caspase independent apoptosis and blocking most of the cells before first division.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Serbia 1 9%
Unknown 10 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 27%
Student > Postgraduate 2 18%
Librarian 1 9%
Professor 1 9%
Unknown 4 36%
Readers by discipline Count As %
Medicine and Dentistry 2 18%
Psychology 2 18%
Arts and Humanities 1 9%
Immunology and Microbiology 1 9%
Social Sciences 1 9%
Other 1 9%
Unknown 3 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2015.
All research outputs
#22,760,732
of 25,377,790 outputs
Outputs from Anti-Cancer Agents in Medicinal Chemistry
#737
of 1,093 outputs
Outputs of similar age
#341,830
of 399,683 outputs
Outputs of similar age from Anti-Cancer Agents in Medicinal Chemistry
#36
of 54 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,093 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 399,683 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.