Title |
Anticancer Activity of Organogallium(III) Complexes in Colon Cancer Cells.
|
---|---|
Published in |
Anti-Cancer Agents in Medicinal Chemistry, January 2016
|
DOI | 10.2174/1871520615666151007160319 |
Pubmed ID | |
Authors |
Milena R Kaluđerović, Marija Mojić, Santiago Gómez-Ruiz, Sanja Mijatović, Danijela Maksimović-Ivanić |
Abstract |
In vitro antitumor activity of various organogallium(III) complexes (1-8) have been tested against CT26CL25, HCT116, SW480 colon cancer cell lines. CV and MTT assays were used to asses on the antiproliferative effect of investigated organogallium(III) complexes. From the investigated complexes the most active was found to be tetranuclear compound 8 against CT26CL25 cells. Flow cytometric analysis of the CT26CL25 cells upon treatment with 8 was performed in order to determine the role of apoptosis, caspase activation, autophagy and proliferation rate on the cell death caused with this compound. Results indicate cytotoxic potential of the tetranuclear complex 8 by inducing caspase independent apoptosis and blocking most of the cells before first division. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Serbia | 1 | 9% |
Unknown | 10 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 27% |
Student > Postgraduate | 2 | 18% |
Librarian | 1 | 9% |
Professor | 1 | 9% |
Unknown | 4 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 2 | 18% |
Psychology | 2 | 18% |
Arts and Humanities | 1 | 9% |
Immunology and Microbiology | 1 | 9% |
Social Sciences | 1 | 9% |
Other | 1 | 9% |
Unknown | 3 | 27% |