Determine if sex differences in glucose uptake, a marker of brain activity, are present in brain regions that facilitate walking performance in persons with MS.
Cross-sectional, observational pilot.
University Laboratory INTERVENTIONS: Not applicable PARTICIPANTS: [(18)F]-Fluorodeoxyglucose (FDG) - positron emission tomography (PET) imaging was performed on persons with MS and healthy controls (HC) (4 men/4 women per group; N = 16) following a 15-minute walking test.
Brain activity was quantified as the mean standardized uptake value (SUVmean).
SUVmean was significantly lower in the thalamus (P = 0.029) and cerebellum (P = 0.029) for men with MS as compared to women with MS, but not for the prefrontal (P = 0.057) or frontal (P = 0.057) cortices. Similar nonsignificant trends were found for the HC. No SUVmean group x sex interaction effects were found between the MS and HC groups (all p-values > 0.05).
This is the first study of brain activity sex differences based on FDG uptake in persons with MS during walking. Significantly less FDG uptake in the thalamus and cerebellum brain regions important for walking performance was found in men with MS compared to women with MS, however these comparisons were not significantly different in the HC group. No differences in FDG uptake were found between the MS and HC groups in any of the brain regions examined. Results from this study provide pilot data for larger studies aimed at identifying underlying mechanisms responsible for accelerated disability in men with MS.
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 February 2016.
All research outputs
#11,913,956
of 34,410,798 outputs
Outputs from Archives of Physical Medicine & Rehabilitation
#3,532
of 7,775 outputs
Outputs of similar age
#112,823
of 315,426 outputs
Outputs of similar age from Archives of Physical Medicine & Rehabilitation
#47
of 79 outputs
Altmetric has tracked 34,410,798 research outputs across all sources so far. This one has received more attention than most of these and is in the 64th percentile.
So far Altmetric has tracked 7,775 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,426 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
