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X Demographics
Mendeley readers
Attention Score in Context
| Title |
THE ACUTE-PHASE PROTEIN &agr;2-MACROGLOBULIN PLAYS AN IMPORTANT ROLE IN RADIOPROTECTION IN THE RAT
|
|---|---|
| Published in |
Shock, June 2009
|
| DOI | 10.1097/shk.0b013e31818bb625 |
| Pubmed ID | |
| Authors |
Mirjana Mihailović, Silva Dobrić, Goran Poznanović, Miodrag Petrović, Aleksandra Uskoković, Jelena Arambasić, Bogojević Bogojević |
| Abstract |
The importance of alpha2-macroglobulin (alpha2M) in natural radioprotection was studied by examining its radioprotective effectiveness in rat models of exogenously and endogenously, preexposure-increased alpha2M. Radioprotective efficacy was ascertained by the postirradiation survival rate, the restoration of body weight, and the leukocyte count, which were monitored during a 4-week follow-up period. The results were compared with the effects of a pretreatment with the synthetic radioprotective agent amifostine (Ami), which provides 100% protection in rats whole-body-irradiated by x-rays given in a dose of 6.7 Gy (LD50/30). Raising the plasma concentration of alpha2M 15-fold in male rats by a single intraperitoneal injection of purified protein provided 100% survival of irradiated animals. Female rats on the 19th day of pregnancy with endogenously elevated levels of alpha2M displayed improved survival (80%) compared with untreated rats (50% survival). After alpha2M administration, the pregnant, irradiated rats exhibited 100% survival. In both males and pregnant females, alpha2M administration promoted body weight and leukocyte postirradiation recovery as in Ami-pretreated rats. These findings, together with our observation that Ami administration induced a 45-fold increase in alpha2M in the circulation, led us to conclude that alpha2M has an essential role in both natural and amifostine-mediated radioprotection in the rat. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Serbia | 1 | 10% |
| Unknown | 9 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Librarian | 2 | 20% |
| Student > Bachelor | 2 | 20% |
| Other | 1 | 10% |
| Professor | 1 | 10% |
| Student > Ph. D. Student | 1 | 10% |
| Other | 1 | 10% |
| Unknown | 2 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 30% |
| Agricultural and Biological Sciences | 1 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 10% |
| Social Sciences | 1 | 10% |
| Physics and Astronomy | 1 | 10% |
| Other | 0 | 0% |
| Unknown | 3 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2012.
All research outputs
#7,959,659
of 25,371,288 outputs
Outputs from Shock
#574
of 3,259 outputs
Outputs of similar age
#40,810
of 125,214 outputs
Outputs of similar age from Shock
#5
of 21 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 3,259 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 125,214 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.