Social scientists have long recognized the important role that neighborhood crime can play in stress-related disease, but very little is known about potential biosocial mechanisms that may link the experience of living in high-crime neighborhoods with depression.
The current study introduces an integrated model that combines neighborhood, genetic, and epigenetic factors.
Hypotheses were tested with a sample of 99 African American women from the Family and Community Health Study (FACHS).
Allele variants of the serotonin transporter gene (5-HTT) interact with neighborhood crime to predict depressive symptoms in a manner consonant with the differential susceptibility perspective. Furthermore, this association is mediated by DNA methylation of the promoter region of the serotonin transporter gene.
The findings provide support for an integrated model in which changes in DNA methylation, resulting from neighborhood crime, can result in an increase or decrease in gene activity which, in turn, influences depressive symptoms.
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2016.
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#20,037,761
of 32,531,496 outputs
Outputs from Social Science & Medicine
#10,693
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#165,744
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Outputs of similar age from Social Science & Medicine
#110
of 137 outputs
Altmetric has tracked 32,531,496 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
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