Neurons require target-derived, autocrine, and paracrine growth factors to maintain proper identity, innervation, homeostasis, and survival. Neuronal growth factor signaling is highly dependent on membrane traffic, both for the packaging and release of the growth factors themselves, and for regulation of intracellular signaling by their transmembrane receptors. Here we review recent findings from the Drosophila larval neuromuscular junction (NMJ) that illustrate how specific steps of intracellular traffic and inter-organelle interactions impinge on signaling, particularly in the Bone Morphogenic Protein (BMP), Wingless (Wg) and c-Jun Activated Kinase (JNK) pathways, regulating elaboration and stability of NMJ arbors, construction of synapses, and synaptic transmission and homeostasis. These membrane trafficking and signaling pathways have been implicated in human motor neuron diseases including Amyotrophic Lateral Sclerosis and Hereditary Spastic Paraplegia, highlighting their importance for neuronal health and survival.
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2019.
All research outputs
#10,351,676
of 33,779,198 outputs
Outputs from Traffic
#422
of 1,394 outputs
Outputs of similar age
#123,369
of 441,962 outputs
Outputs of similar age from Traffic
#4
of 18 outputs
Altmetric has tracked 33,779,198 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,394 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 441,962 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.
