We performed untargeted metabolomics of plasma from B6 mice with experimental autoimmune encephalitis (EAE) at the chronic phase of the disease in search of an altered metabolic pathway(s). Of 324 metabolites measured, 100 metabolites that mapped to various pathways (mainly lipids) linked to mitochondrial function, inflammation and membrane stability were observed to be significantly altered between EAE and healthy control (p < 0.05, false discover rate [< 0.10]. Bioinformatics analysis revealed 6 metabolic pathways being impacted and altered in EAE including alpha linolenic acid and linoleic acid metabolism (PUFA). The metabolites of PUFAs, including omega 3 and omega 6 fatty acids, are commonly decreased in mouse models and in multiple sclerosis patients. Daily oral administration of resolvin D1, a downstream metabolite of omega 3, decreased disease progression by suppressing autoreactive T cells and inducing a M2 phenotype of monocytes/macrophages and resident brain microglial cells. This study provides a proof of principle for the application of a metabolomic approach to identify endogenous metabolite(s) possessing drug-like properties, which is tested for therapy in preclinical mouse models.
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2020.
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#4,719,778
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#4,131
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#50,834
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Outputs of similar age from Journal of Biological Chemistry
#72
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Altmetric has tracked 33,825,399 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 29,479 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done well, scoring higher than 85% of its peers.
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We're also able to compare this research output to 503 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.
