The chemical and mechanical properties of extracellular matrices (ECM) modulate diverse aspects of cellular fates; however, how regional heterogeneity in the ECM composition regulates developmental programs is not well understood. We discovered that Fn1 is expressed in strikingly non-uniform patterns during mouse development, suggesting that regionalized synthesis of the ECM plays cell-specific regulatory roles during embryogenesis. To test this hypothesis, we ablated Fn1 in the neural crest (NC), a population of multi-potent progenitors expressing high levels of Fn1. We found that Fn1 synthesized by the NC mediated aortic arch artery morphogenesis and the differentiation of NC cells into vascular smooth muscle cells (VSMCs) by regulating Notch signaling. We demonstrate that NC Fn1 signals in neural crest cell-autonomous manner through integrin α5β1 expressed by the NC leading to the activation of Notch and the differentiation of VSMCs. Our data demonstrate an essential role of the localized synthesis of Fn1 in cardiovascular development and spatial regulation of Notch signaling.
Pharmacology, Toxicology and Pharmaceutical Science
1
2%
Other
4
7%
Unknown
9
16%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2016.
All research outputs
#31,576,053
of 34,763,505 outputs
Outputs from Development (09501991)
#11,340
of 11,613 outputs
Outputs of similar age
#285,971
of 324,624 outputs
Outputs of similar age from Development (09501991)
#95
of 98 outputs
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We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
