We investigated the physiologic impact of acute maternal hyperoxygenation (MH) in human fetuses with and without congenital heart disease (CHD) using fetal cardiac MR (CMR) in order to explore the potential therapeutic benefits of chronic MH.
We examined 17 normal and 20 late-gestation human fetuses with CHD on a 1.5T CMR system. Flows were measured in major fetal vessels using phase contrast MRI. The T2 of umbilical venous (UV) blood was measured using T2 mapping. The measurements were repeated during acute MH. The results were compared using a Student's t-test, with p-value ≤0.05 considered statistically significant.
At baseline, the UV T2 (oxygen saturation) was lower in CHD fetuses than in normals, with significant increase with MH (p=0.01). Both groups showed significant increase in pulmonary blood flow during MH, which was more dramatic in CHD (p=0.005). There was a reduction in ductus arteriosus flow in CHD during MH (p=0.04). There was no significant difference in blood flow in any of the other major vessels.
This study suggests that fetal MR identifies the expected hemodynamic changes associated with acute MH. MRI could be useful as a method for monitoring the impact of chronic MH in fetuses with CHD. This article is protected by copyright. All rights reserved.
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2015.
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#4,835,465
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Outputs from Prenatal Diagnosis
#341
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#78,856
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Outputs of similar age from Prenatal Diagnosis
#20
of 38 outputs
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