There is increasing interest in targeting histone N-methyl-lysine demethylases (KDM) with small molecules both for the generation of probes for target exploration and for therapeutic purposes. Here we update on previous reviews on the inhibition of the lysine-specific demethylases (LSDs or KDM1s) and JmjC families of N-methyl-lysine demethylases (JmjC KDMs, KDM2-7) focusing on the academic and patent literature from 2014 to date. We also highlight recent biochemical, biological and structural studies which are relevant to KDM inhibitor development.
Pharmacology, Toxicology and Pharmaceutical Science
20
9%
Medicine and Dentistry
7
3%
Other
11
5%
Unknown
47
21%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2025.
All research outputs
#3,635,082
of 27,744,365 outputs
Outputs from Journal of Medicinal Chemistry
#3,540
of 24,023 outputs
Outputs of similar age
#56,168
of 413,589 outputs
Outputs of similar age from Journal of Medicinal Chemistry
#41
of 164 outputs
Altmetric has tracked 27,744,365 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 24,023 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 413,589 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 164 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
