An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels

Overview of attention for article published in Nature Communications, January 2016

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An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels. https://t.co/5DYgRzHDwP

An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels https://t.co/UgVerNVGgl

Ca有無のCx26構造。Ca結合によりチャネルがブロックされるのは知られていたが、その理由が「サブユニットの構造変化によりチャネルが物理的に塞がれる」為ではなく「チャネル内の静電ポテンシャルが変化し陽イオン透過が阻害される」為と示したhttps://t.co/Gg0JJRnYDc

RT @t2438: だいぶ前に学会で発表していたというCx26の(高)分解能構造。Ca2+の結合によってporeの電位状態を変化させることで物質透過の制御を行うという、いわゆるプラグモデルとはまったく異なるメカニズムを提唱。とりあえず読んでみる。https://t.co/sS…

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