Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

Overview of attention for article published in Cell, October 2018

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ケースコントロール研究でMSの遺伝性リスクの５％を説明する低頻度バリアントコーディングを同定。一般バリアントシグナルと独立し、Tregに関連するドライブ遺伝子を4つ発見した、と：IMSG　Consortium。 https://www.cell.com/c…

In a large multi-cohort study, unexplained heritability for multiple sclerosis is detected in low-frequency coding variants…

20% of MS risk heritability can be attributed to common genetic variants four novel genes driving risk independently of common-va…

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