Activation of free fatty acid receptor (FFAR)2 and FFAR3 via colonic short-chain fatty acids, particularly propionate, are postulated to explain observed inverse associations between dietary fiber intake and body weight. Propionate is reported as the predominant colonic fermentation product from L-rhamnose, a natural monosaccharide that resists digestion and absorption reaching the colon intact, while effects of long-chain inulin on appetite have not been extensively investigated. In this single-blind randomized crossover study, healthy unrestrained eaters (n=13) ingested 25.5 g/d L-rhamnose, 22.4 g/d inulin or no supplement (control) alongside a standardized breakfast and lunch, following a 6-d run-in to investigate if appetite was inhibited. Postprandial qualitative appetite, breath hydrogen, and plasma glucose, insulin, triglycerides and non-esterified fatty acids were assessed for 420 min, then an ad libitum meal was provided. Significant treatment x time effects were found for postprandial insulin (P=0.009) and non-esterified fatty acids (P=0.046) with a significantly lower insulin response for L-rhamnose (P=0.023) than control. No differences between treatments were found for quantitative and qualitative appetite measures, although significant treatment x time effects for meal desire (P=0.008) and desire to eat sweet (P=0.036) were found. Breath hydrogen was significantly higher with inulin (P=0.001) and L-rhamnose (P=0.009) than control, indicating colonic fermentation. These findings suggest L-rhamnose may inhibit postprandial insulin secretion, however neither L-rhamnose or inulin influenced appetite.
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2020.
All research outputs
#7,356,343
of 25,374,647 outputs
Outputs from Appetite
#2,489
of 4,785 outputs
Outputs of similar age
#101,830
of 380,106 outputs
Outputs of similar age from Appetite
#46
of 79 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 4,785 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.0. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
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We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
