Adverse effects of different types of medication can cause various patterns of colitis.(1) The immunosuppresive drugs Mycophenolic acid and anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) antibody Ipilimumab are known to cause a graft-versus-host disease (GVHD)-like apoptotic enteropathy (AE).(1,2) Recently, antimetabolites (Methotrexate and Capecitabine) and tumour necrosis factor-α (TNF-α) inhibitors (Etanercept and Infliximab) have also been reported to cause similar changes.(2) Adalimumab is a fully humanized anti TNF-α monoclonal antibody that has been approved by the Food and Drug Administration (FDA) for use in Crohn's disease and ulcerative colitis (UC).(3,4) Here we present a case of apoptic enteropathy (AE) in a patient with ulcerative colitis, who was being treated with Adalimumab. To best of our knowledge, this is the first such case reported in the literature. This article is protected by copyright. All rights reserved.