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Mendeley readers
Attention Score in Context
| Title |
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease
|
|---|---|
| Published in |
Progress in Neurobiology, January 2016
|
| DOI | 10.1016/j.pneurobio.2015.12.003 |
| Pubmed ID | |
| Authors |
Lhassane Ismaili, Bernard Refouvelet, Mohamed Benchekroun, Simone Brogi, Margherita Brindisi, Sandra Gemma, Giuseppe Campiani, Slavica Filipic, Danica Agbaba, Gerard Esteban, Mercedes Unzeta, Katarina Nikolic, Stefania Butini, José Marco-Contelles |
| Abstract |
Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid fibril deposition, and β-amyloid oligomers formation. Based on the involvement of a relevant number of biological systems in Alzheimer's disease progression, multitarget compounds may enable therapeutic efficacy. Accordingly, compounds possessing, besides anticholinergic activity and β-amyloid aggregation inhibition properties, metal chelating and/or nitric oxide releasing properties with additional antioxidant capacity were developed. Other targets relevant to Alzheimer's disease have also been considered in the last years for producing multitarget compounds such as β-secretase, monoamino oxidases, serotonin receptors and sigma 1 receptors. The purpose of this review will be to highlight recent reports on the development of multitarget compounds for Alzheimer's disease published within the last years focusing on multifunctional ligands characterized by tacrine-like and donepezil-like structures. |
Mendeley readers
The data shown below were compiled from readership statistics for 185 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 183 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 14% |
| Student > Master | 23 | 12% |
| Student > Bachelor | 19 | 10% |
| Professor > Associate Professor | 13 | 7% |
| Student > Doctoral Student | 13 | 7% |
| Other | 37 | 20% |
| Unknown | 54 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 42 | 23% |
| Pharmacology, Toxicology and Pharmaceutical Science | 33 | 18% |
| Biochemistry, Genetics and Molecular Biology | 10 | 5% |
| Agricultural and Biological Sciences | 9 | 5% |
| Medicine and Dentistry | 6 | 3% |
| Other | 21 | 11% |
| Unknown | 64 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2016.
All research outputs
#4,835,823
of 25,373,627 outputs
Outputs from Progress in Neurobiology
#479
of 1,356 outputs
Outputs of similar age
#76,310
of 401,828 outputs
Outputs of similar age from Progress in Neurobiology
#8
of 14 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,356 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 401,828 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.