Transbronchial forceps biopsy (FBx) has been the preferred method for obtaining bronchoscopic lung biopsy. Cryoprobe biopsy (CBx) has been shown to obtain larger and higher quality samples but has been limited by the inability to retrieve the sample through the working channel of the bronchoscope requiring the bronchoscope to leave the airway for sample retrieval. We evaluate a novel device using a sheath cryobiopsy (SCBx) allowing for specimen retrieval through the working channel of the bronchoscope with the scope remaining inside the airway.
Prospective, randomized, controlled, single blinded porcine study comparing a 1.1 mm SCBx probe, 1.9 mm CBx probe and 2.0 mm FBx forceps. Assessment of histological assessability, sample quantity and quality, number of attempts to acquire and retrieve samples, cryoprobe activation time, fluoroscopy activation time, technical feasibility and complications were compared.
Specimens adequate for standard pathologic processing were retrieved with 82.1% of the SCBx specimens, 82.9%% of the CBx and 30% of the FBx. The histologic assessability of both, SCBx (p =0.0002) and CBx (p=0.0003) was superior over FBx. Procedure time for FBx was faster than both SCBx and CBx, but SCBx was significantly faster than CBx (p<0.0001). Fluoroscopy time was lower for both SCBx and CBx as compared to FBx. There were no significant bleeding events.
SCBx is a feasible technique providing a higher quality lung biopsy compared to FBx and can successfully be retrieved through the working channel. Human studies are needed to further assess this technique with additional safety data.
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2021.
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