Title |
Did the Iceman Know Better? Screening of the Medicinal Properties of the Birch Polypore Medicinal Mushroom, Piptoporus betulinus (Higher Basidiomycetes)
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Published in |
International Journal of Medicinal Mushrooms, January 2015
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DOI | 10.1615/intjmedmushrooms.v17.i12.10 |
Pubmed ID | |
Authors |
Jovana Vunduk, Anita Klaus, Maja Kozarski, Predrag Petrovic, Zeljko Zizak, Miomir Niksic, Leo J L D Van Griensven |
Abstract |
The birch polypore Piptoporus betulinus was among two mushrooms that were found in the Iceman's bag. Recent studies indicated that P. betulinus was probably used as a religious and medicinal item. In order to examine the medicinal potential of P. betulinus, hot water (HW), partially purified (PP), and alkali extract (HA) were prepared and tested for antioxidant, antimicrobial, cytotoxic, and angiotensin I-converting enzyme (ACE) inhibitory activity. All tested samples exhibited moderate cytotoxic activity, and HW appeared as the most effective (IC50 = 0.8 ± 0.1 mg/ml for HeLa cells). HA proved to be a good 1,1-diphenyl-2-picrylhydrazyl radical scavenger and exhibited the strongest ferric-reducing power (EC50 = 0.07 ± 0.3 mg/ml). The same extract (HA) also expressed the strongest ferric-reducing power (EC50 = 0.99 ± 0.1 mg/ml). Hot alkali extraction contributed significantly to ACE inhibitory activity (EC50 = 0.06 ± 0.00 mg/ml) and to antimicrobial activity, especially against highly resistant Enterococcus faecalis (minimum inhibitory concentration: 0.156 ± 0.000 mg/ml; and minimum bactericidal concentration: 1.25 ± 0.00 mg/ml). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 3% |
Unknown | 28 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 28% |
Professor | 4 | 14% |
Student > Bachelor | 2 | 7% |
Student > Ph. D. Student | 2 | 7% |
Student > Master | 1 | 3% |
Other | 3 | 10% |
Unknown | 9 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 21% |
Biochemistry, Genetics and Molecular Biology | 5 | 17% |
Immunology and Microbiology | 4 | 14% |
Chemistry | 2 | 7% |
Business, Management and Accounting | 1 | 3% |
Other | 3 | 10% |
Unknown | 8 | 28% |