It is generally accepted that CD8+ T cell responses play an important role in control of immunodeficiency virus replication. The association of HLA-B27 and -B57 with control of viremia supports this conclusion. However, specific correlates of viral control in individuals expressing these alleles have been difficult to define. We recently reported that transient in vivo CD8+ cell depletion in simian immunodeficiency virus (SIV)-infected elite controller (EC) macaques resulted in a brief period of viral recrudescence. SIV replication was rapidly controlled with the reappearance of CD8+ cells, implicating that these cells actively suppress viral replication in ECs.
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2007.
All research outputs
#24,918,520
of 34,559,526 outputs
Outputs from PLOS ONE
#158,012
of 225,087 outputs
Outputs of similar age
#111,920
of 124,209 outputs
Outputs of similar age from PLOS ONE
#235
of 255 outputs
Altmetric has tracked 34,559,526 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 225,087 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.2. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
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