Structural basis of α-scorpion toxin action on Nav channels

Overview of attention for article published in Science, February 2019

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Fast inactivation is an essential part of voltage gated sodium channel function, and its disruption is linked to multiple diseases. Clairfeuille et al. use a scorpion toxin that impedes fast inactivation to gain structural insights into the inactivation…

Another cool @genentech collaboration, another voltage-sensor domain of a sodium channel caught in deactivated and activated states by cryoEM. http://science.sciencemag.org/content/early/2019/02/06/science.aav8573.full

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