Due to its widespread use in the manufacturing of consumer products over several decades, human exposure to bisphenol A (BPA) has been pervasive. Fetuses are particularly sensitive to BPA exposure, with a number of negative developmental and reproductive outcomes observed in rodent perinatal models. Xenobiotic transporters are one mechanism to extrude conjugated and unconjugated BPA from liver. In this study, the mRNA expression of xenobiotic transporters and relationships with total, conjugated, and free BPA levels were explored utilizing human fetal liver samples. The mRNA expression of BCRP and MRP4, as well as BCRP and MDR1 exhibited the highest degree of correlation, with r-squared values of 0.941 (p<0.001) and 0.816 (p<0.001), respectively. Increasing concentrations of conjugated BPA significantly correlated with high expression of MRP1 (p<0.001), MRP2 (p<0.05), and MRP3 (p<0.05) transporters, in addition to the transcription factor NRF2 (p<0.001) and its prototypical target gene, NQO1 (p<0.001). These data demonstrate that xenobiotic transporters may be coordinately expressed in the human fetal liver. This is also the first report of a relationship between environmentally-relevant fetal BPA levels and differences in the expression of transporters that can excrete the parent compound and its metabolites.
Pharmacology, Toxicology and Pharmaceutical Science
5
13%
Agricultural and Biological Sciences
5
13%
Biochemistry, Genetics and Molecular Biology
3
8%
Environmental Science
2
5%
Other
5
13%
Unknown
12
30%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2018.
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#22,759,452
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Outputs from Drug Metabolism and Disposition
#2,352
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of 406,031 outputs
Outputs of similar age from Drug Metabolism and Disposition
#26
of 27 outputs
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