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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
|
|---|---|
| Published in |
Nature, June 2001
|
| DOI | 10.1038/35082088 |
| Pubmed ID | |
| Authors |
Huai-hu Chuang, Elizabeth D. Prescott, Haeyoung Kong, Shannon Shields, Sven-Eric Jordt, Allan I. Basbaum, Moses V. Chao, David Julius |
| Abstract |
Tissue injury generates endogenous factors that heighten our sense of pain by increasing the response of sensory nerve endings to noxious stimuli. Bradykinin and nerve growth factor (NGF) are two such pro-algesic agents that activate G-protein-coupled (BK2) and tyrosine kinase (TrkA) receptors, respectively, to stimulate phospholipase C (PLC) signalling pathways in primary afferent neurons. How these actions produce sensitization to physical or chemical stimuli has not been elucidated at the molecular level. Here, we show that bradykinin- or NGF-mediated potentiation of thermal sensitivity in vivo requires expression of VR1, a heat-activated ion channel on sensory neurons. Diminution of plasma membrane phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) levels through antibody sequestration or PLC-mediated hydrolysis mimics the potentiating effects of bradykinin or NGF at the cellular level. Moreover, recruitment of PLC-gamma to TrkA is essential for NGF-mediated potentiation of channel activity, and biochemical studies suggest that VR1 associates with this complex. These studies delineate a biochemical mechanism through which bradykinin and NGF produce hypersensitivity and might explain how the activation of PLC signalling systems regulates other members of the TRP channel family. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 442 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| Germany | 3 | <1% |
| Chile | 2 | <1% |
| Spain | 2 | <1% |
| Italy | 1 | <1% |
| United Kingdom | 1 | <1% |
| Russia | 1 | <1% |
| Netherlands | 1 | <1% |
| Japan | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 425 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 88 | 20% |
| Researcher | 74 | 17% |
| Student > Bachelor | 55 | 12% |
| Student > Master | 42 | 10% |
| Professor > Associate Professor | 26 | 6% |
| Other | 73 | 17% |
| Unknown | 84 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 145 | 33% |
| Neuroscience | 63 | 14% |
| Medicine and Dentistry | 51 | 12% |
| Biochemistry, Genetics and Molecular Biology | 37 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 3% |
| Other | 39 | 9% |
| Unknown | 93 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2022.
All research outputs
#1,668,280
of 22,893,031 outputs
Outputs from Nature
#38,288
of 91,096 outputs
Outputs of similar age
#1,324
of 39,720 outputs
Outputs of similar age from Nature
#52
of 355 outputs
Altmetric has tracked 22,893,031 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 91,096 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 99.4. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 39,720 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 355 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.