Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations

UNC-8 forms homomeric channels in Xenopus oocytes (https://t.co/8ENPjN0mU8). MEC-4, but not MEC-10 also forms homomeric channels in oocytes (https://t.co/tgx0qC26YN). Thus, some, but not all DEG/ENaC/ASIC channels run solo and others need partners/6